Publications
2025
Learning the dynamic organization of a replicating bacterial chromosome from time-course Hi-C data
Janni Harju, Joris J.B. Messelink, Lucas Tröger, Grzegorz Gradziuk, Imesha Rathnayaka, Martin Thanbichler, Muriel C.F. van Teeseling, Chase P. Broedersz
[bioRxiv: 2025.04.03.647011]
Loop-extruder mediated rigidity can globally order bacterial chromosomes
Janni Harju, Till Armbruster, Chase P. Broedersz
PRX Life 3, 013014 (2025) [bioRxiv 2024.10.10.617531]
2024
Ion-mediated condensation controls the mechanics of mitotic chromosomes
Hannes Witt, Janni Harju, Emma M.J. Chameau, Charlotte M.A. Bruinsma, Tinka V.M. Clement, Christian F. Nielsen, Ian D. Hickson, Erwin J.G. Peterman, Chase P. Broedersz, Gijs J.L. Wuite
Nat. Mater. (2024) [biorXiv: 2023.04.11.536423]
Nonequilibrium Probability Currents in Optically-Driven Colloidal Suspensions
Samudrajit Thapa, Daniel Zaretzky, Ron Vatash, Grzegorz Gradziuk, Chase Broedersz, Yair Shokef, Yael Roichman
SciPost Phys. 17, 096 (2024)
Resolving interface structure and local internal mechanics of mitotic chromosomes
Andrea Ridolfi, Hannes Witt, Janni Harju, Tinka V. M. Clement, Erwin E. J. G. Peterman, Chase P. Broedersz, Gijs J. L. Wuite
[bioRxiv: 2024.08.20.608279]
Data-driven theory reveals protrusion and polarity interactions governing collision behavior of distinct motile cells
Tom Brandstätter, Emily Brieger, David B. Brückner, Georg Ladurner, Joachim Rädler, Chase P. Broedersz
[arxiv:2407.17268]
Nuclear deformation and dynamics of migrating cells in 3D confinement reveal adaptation of pulling and pushing forces
Stefan Stöberl*, Johannes Flommersfeld*, Max Kreft, Martin Benoit, Chase P. Broedersz+, Joachim O. Rädler+
Sci. Adv. 10,eadm9195 (2024) [BioRxiv:0.1101/2023.10.30.564765v1]
Unravelling the metastasis-preventing effect of miR-200c in vitro and in vivo
Bianca Köhler, Emily Brieger, Tom Brandstätter, Elisa Hörterer, Ulrich Wilk, Jana Pöhmerer, Anna Jötten, Philipp Paulitschke, Chase P. Broedersz, Stefan Zahler, Joachim O Rädler, Ernst Wagner, Andreas Roidl
Mol. Oncol. 19: 1029-1053 (2025) [bioarXiv: 2023.11.14.566527]
Loop-extruders alter bacterial chromosome topology to direct entropic forces for segregation
Janni Harju, Muriel C. F. van Teeseling, Chase P. Broedersz
Nat. Commun. 15 4618 (2024) [bioarXiv: 2023.06.30.547230]
Physical models of bacterial chromosomes
Janni Harju, Chase P. Broedersz
Molecular Microbiology, 00, 1–11 (2024) [arXiv:2312.09328]
Learning dynamical models of single and collective cell migration: a review
David Brückner, Chase P. Broedersz
Rep. Prog. Phys. 87 056601 (2024) [arXiv:2309.00545]
Geometry-sensitive protrusion growth directs confined cell migration
Johannes Flommersfeld, Stefan Stöberl, Omar Shah, Joachim O. Rädler, Chase P. Broedersz
Physical Review Letters, 132, 098401 (2024) [arXiv:2308.08372]
Nonlinear mechanosensation in fiber networks
Estelle Berthier, Haiqian Yang, Ming Guo, Pierre Ronceray, Chase P. Broedersz
Phys. Rev. Research 6 013327 (2024) [arXiv:2208.06328v1]
2023
Local Response and Emerging Nonlinear Elastic Lengthscale in Biopolymer Matrices
Haiqian Yang , Estelle Berthier, Chenghai Li, Pierre Ronceray, Yu Long Han, Chase P. Broedersz, Shengqiang Cai, Ming Guo
PNAS 120 (23) e2304666120 [arXiv:2208.06386]
Curvature induces active velocity waves in rotating spherical tissues
Tom Brandstätter, David B. Brückner, Yu Long Han, Ricard Alert, Ming Guo, Chase P. Broedersz
Nat. Commun. 14 1643 (2023) [arXiv:2110.14614]
2022
Geometry adaptation of protrusion and polarity dynamics in confined cell migration
David B. Brückner, Matthew Schmitt, Alexandra Fink, Georg Ladurner, Johannes Flommersfeld, Nicolas Arlt, Edouard Hannezo, Joachim O. Rädler, Chase P. Broedersz
Phys. Rev. X 12, 031041, Physics Magazine, [arXiv:2106.01014]
3D printed protein-based robotic structures actuated by molecular motor assemblies
Haiyang Jia, Johannes Flommersfeld, Michael Heymann, Sven K. Vogel, Henri G. Franquelim, David B. Brückner, Hiromune Eto, Chase P. Broedersz+, Petra Schwille+
Nature Materials 21, 703–709 (2022) [preprint]
Twenty-five years of nanoscale thermodynamics
Chase P. Broedersz and Pierre Ronceray
Nature, News and Views (2022)
Nonlinear mechanics of human mitotic chromosomes
Anna E.C. Meijering, Kata Sarlós, Christian F. Nielsen, Hannes Witt, Janni Harju, Emma Kerklingh, Guus H. Haasnoot, Anna H. Bizard, Iddo Heller, Chase P. Broedersz+, Ying Liu, Erwin J. G. Peterman, Ian D. Hickson, Gijs J. L. Wuite+
Nature (2022)
Irreversibility in linear systems with colored noise
Grzegorz Gradziuk, Gabriel Torregrosa, Chase P. Broedersz
Physical Review E 105, 024118 (2022) [arXiv:2111.07359]
2021
Disentangling cadherin-mediated cell-cell interactions in collective cancer cell migration
Themistoklis Zisis, David B. Brückner, Tom Brandstätter, Joseph d’Alessandro, Angelika M. Vollmar, Chase P. Broedersz, Stefan Zahler
Biophys. J. 121, 44-60 (2021) [bioRxiv:2021.05.07.442718]
Single-cell growth inference of Corynebacterium glutamicum reveals asymptotically linear growth
Joris J. B. Messelink, Fabian Meyer, Marc Bramkamp, Chase P. Broedersz
eLife 10, e70106 (2021) [bioRxiv:2020.05.25.115055]
Learning the Distribution of Single-Cell Chromosome Conformations in Bacteria Reveals Emergent Order across Genomic Scales
Joris J. B. Messelink, Muriel C. F. van Teeseling, Jacqueline Janssen, Martin Thanbichler, and Chase P. Broedersz
Nat. Commun. 12, 1 (2021) [arXiv:2002.03880]
Learning the dynamics of cell-cell interactions in confined cell migration
David B. Brückner, Nicolas Arlt, Alexandra Fink, Pierre Ronceray, Joachim O. Rädler, Chase P. Broedersz
PNAS 118 (7), e2016602118 (2021) [arXiv:2008.03978] [LMU Press Release]
Theory of Active Intracellular Transport by DNA-relaying
Christian Hanauer, Silke Bergeler, Erwin Frey, Chase P. Broedersz
Physical Review Letters 127, 138101 (2021) [arXiv:2101.02640]
2020
Learning the Non-Equilibrium Dynamics of Brownian Movies
Federico S. Gnesotto, Grzegorz Gradziuk, Pierre Ronceray, Chase P. Broedersz
Nature Communications 11, 5378 (2020) [arXiv:2001.08642]
Inferring the Dynamics of Underdamped Stochastic Systems
David B. Brückner, Pierre Ronceray, Chase P. Broedersz
Physical Review Letters 125, 058103 (2020), featured as Editors’ suggestion [arXiv:2002.06680]
Disentangling the Behavioural Variability of Confined Cell Migration
David B. Brückner, Alexandra Fink, Joachim O. Rädler, Chase P. Broedersz
Journal of the Royal Society Interface 17, 20190689 (2020) [arXiv:1910.02815] [bioRxiv:10.1101/797555]
Area and geometry dependence of cell migration in asymmetric two-state micropatterns
Alexandra Fink, David B. Brückner, Christoph Schreiber, Peter Röttgermann, Chase P. Broedersz, Joachim O. Rädler
Biophysical Journal, 118, 552-564 (2019) [bioRxiv:10.1101/815472]
Lattice Kinetic Monte-Carlo Method for Simulating Chromosomal Dynamics and other (Non-)Equilibrium Bio-Assemblies
Christiaan A. Miermans, Chase P. Broedersz
Soft Matter 16, 544-556 (2020)
Morphology and Motility of Cells on Soft Substrates
Andriy Goychuk, David B. Brückner, Andrew W. Holle, Joachim P. Spatz, Chase P. Broedersz, Erwin Frey
submitted for publication [arXiv:1808.00314]
2019
Mesoscopic non-equilibrium measures can reveal intrinsic features of the active driving
Federica Mura, Grzegorz Gradziuk, Chase P. Broedersz
Soft Matter 15, 8067-8076 (2019) [arXiv:1905.13663]
Non-equilibrium dynamics of isostatic spring networks
Federico S. Gnesotto, Benedikt M. Remlein, Chase P. Broedersz
Physical Review E 100, 013002 (2019) [arXiv:1809.04639]
Scaling behavior of non-equilibrium measures in internally driven elastic assemblies
Grzegorz Gradziuk, Federica Mura, Chase P. Broedersz
Physical Review E 99, 052406 (2019) [arXiv:1901.03132]
Stochastic nonlinear dynamics of confined cell migration in two-state systems
David B. Brückner, Alexandra Fink, Christoph Schreiber, Peter Röttgermann, Joachim O. Rädler, Chase P. Broedersz
Nature Physics 15, 595–601 (2019) [Nature Physics News & Views] [LMU Press Release]
Fiber plucking by molecular motors yields large emergent contractility in stiff biopolymer networks
Pierre Ronceray, Chase P. Broedersz, Martin Lenz
Soft Matter 15, 1481-1487 (2019) [arXiv:1805.04624]
2018
Stress-dependent amplification of active forces in nonlinear elastic media
Pierre Ronceray, Chase P. Broedersz, Martin Lenz
Soft Matter 15, 331-338 (2019) [arXiv:1805.02779]
Bacterial chromosome organization by collective dynamics of SMC condensins
Christiaan A. Miermans, Chase P. Broedersz
J. R. Soc. Interface 15, 20180495 (2018) [arXiv:1805.03983]
Non-equilibrium scaling behaviour in driven soft biological assemblies
Federica Mura, Grzegorz Gradziuk, Chase P. Broedersz
Phys. Rev. Lett. 121 (3), 038002 (2018) [arXiv:1803.02797]
Broken detailed balance and non-equilibrium dynamics in living systems
Federico S. Gnesotto, Federica Mura, Jannes Gladrow, Chase P. Broedersz
Rep. Prog. Phys. 81, 6 (2018) [arXiv:1710.03456]
Guiding 3D cell migration in deformed synthetic hydrogel microstructures
Miriam Dietrich, Hugo Le Roy, David B. Brückner, Hanna Engelke, Roman Zantl, Joachim O. Rädler, Chase P. Broedersz
Soft Matter 14, 2816-2826 (2018)
Looping and clustering model for the organization of partitioning proteins on the bacterial genome
Jean-Charles Walter, Jérôme Dorignac, Frédéric Geniet, John Palmeri, Andrea Parmeggiani, Ned S. Wingreen, Chase P. Broedersz
New J. Phys. 20, 035002 (2018) [arXiv:1707.01373]
Cell contraction induces long-ranged stress stiffening in the extracellular matrix
Yu Long Han, Pierre Ronceray, Guoqiang Xu, Andrea Malandrino, Martin Lenz, Chase P. Broedersz+, Ming Guo+
PNAS 115 (16), 4075-4080 (2018) [arXiv:1709.00793]
2017
Nonequilibrium dynamics of probe filaments in actin-myosin networks
Jannes Gladrow, Chase P. Broedersz, Christoph F. Schmidt
Phys. Rev. E 96, 022408 (2017) [arXiv:1704.06243]
Physical limits to biomechanical sensing in disordered fibre networks
Farzan Beroz, Louise M. Jawerth, Stefan Münster, David A. Weitz, Chase P. Broedersz, Ned S. Wingreen
Nat. Commun. 8, 16096 (2017) [arXiv:1608.01620]
2016
Broken Detailed Balance of Filament Dynamics in Active Networks
Jannes Gladrow, Nikta Fakhri, Fred C. MacKintosh, Christoph F. Schmidt, Chase P. Broedersz
Phys. Rev. Lett. 116 (24), 248301 (2016) [arXiv:1603.04783]
Broken detailed balance at the mesoscale in active biological systems
Christopher Battle*, Chase P. Broedersz*, Nikta Fakhri*, Veikko F. Geyer, Jonathon Howard, Christoph F. Schmidt, Fred C. MacKintosh
Science 352, 604-607 (2016)
Fiber networks amplify active stress
Pierre Ronceray, Chase P. Broedersz, Martin Lenz
PNAS 113 (11), 2827–2832 (2016)
Multi-scale strain-stiffening of semiflexible bundle networks
Izabela K. Piechocka, Karin A. Jansen, Chase P. Broedersz, Nicholas A. Kurniawan, Fred C. MacKintosh, Gijsje H. Koenderink
Soft Matter Advance Article 12 (7), 2145-2156 (2016) [arXiv:1206.3894]
2015
Soft viscoelastic properties of nuclear actin age oocytes due to gravitational creep
Marina Feric, Chase P. Broedersz, Clifford P. Brangwynne
Scientific Reports 5, 16607 (2015)
Statistical mechanics of the US Supreme Court
Edward D. Lee, Chase P. Broedersz, Wiliam Bialek
J. Stat. Phys. 1, 0022-4715 (2015) [arXiv:1306.5004]
2014
Condensation and localization of the partitioning protein ParB on the bacterial chromosome
Chase P. Broedersz, Xindan Wang, Yigal Meir, Joseph J. Loparo, David Z. Rudner, Ned S. Wingreen
PNAS 111 (24), 8809-8814 (2014)
Modeling semiflexible polymer networks
Chase P. Broedersz, Fred C. MacKintosh
Rev. of Mod. Phys. 86, 995 (2014) [arXiv:1404.4332]
A New Approach to Analyze Nonlinear Stress Response in Large Amplitude Oscillatory (LAOS) measurement using Parallel Plates
Zahra Fahimi, Chase P. Broedersz, Thomas H. S. van Kempen, Daniel Florea, Gerrit W. M. Peters, Hans M. Wyss
Rheologica Acta 53, 75-83 (2014)
2013
Nuclear mechanics: Lamin webs and pathological blebs
Chase P. Broedersz, Clifford P. Brangwynne
Nucleus 4 (3), 156-159 (2013)
Dynamical behavior of disordered spring networks
Miles G. Yucht , Michael Sheinman, Chase P. Broedersz
Soft Matter 9, 7000-7006 (2013) [arXiv:1301.3574]
Stress-enhanced Gelation: A Dynamic Nonlinearity of Elasticity
Norman Y. Yao, Chase P. Broedersz, Martin Depken, Daniel J. Becker, Martin R. Pollak, Fred C. MacKintosh, David A. Weitz
Phys. Rev. Lett. 110, 018103 (2013)
Attenuated short wavelength buckling and force propagation in a biopolymer-reinforced rod
Wanliang L. Shan, Zi Chen, Chase P. Broedersz, A. A. Gumaste, Winston Soboyejo, Clifford P. Brangwynne
Soft Matter 9, 194-199 (2013)
2012
Actively stressed marginal networks
Michael Sheinman, Chase P. Broedersz, Fred C. MacKintosh
Phys. Rev. Lett. 109, 238101 (2012) [arXiv:1206.4152]
Filament-Length-Controlled Elasticity in 3D Fiber Networks
Chase P. Broedersz, Michael Sheinman, Fred C. MacKintosh
Phys. Rev. Lett. 108, 078102 (2012) [arXiv:1108.4354]
Nonlinear effective medium theory of disordered spring networks
Michael Sheinman, Chase P. Broedersz, Fred C. MacKintosh
Phys. Rev. E 85, 021801 (2012) [arXiv:1108.3981]
2011
Criticality and isostaticity in fiber networks
Chase P. Broedersz, Xiaoming Mao, Tom C. Lubensky, Fred C. MacKintosh
Nature Physics 7, 983-988 (2011) [arXiv:1011.6535]
Molecular motors stiffen non-affine semiflexible polymer networks
Chase P. Broedersz, Fred C. MacKintosh
Soft Matter 7, 3186-3191 (2011) [arXiv:1009.3848]
Nonlinear Viscoelasticity of Actin Transiently Cross-linked with Mutant alpha-Actinin-4
Norman Y. Yao, Daniel Becker, Chase P. Broedersz, Martin Depken, Martin R. Pollak, Fred C. MacKintosh, David A. Weitz
Journal of Molecular Biology 411 (5), 1062-1071 (2011)
2010
Cross-link governed dynamics of biopolymer networks
Chase P. Broedersz, Martin Depken, Norman Y. Yao, Martin R. Pollak, David A. Weitz, Fred C. MacKintosh
Phys. Rev. Lett. 105, 238101 (2010) [arXiv:1006.3940]
Measurement of nonlinear rheology of cross-linked biopolymer gels
Chase P. Broedersz, Karen E. Kasza, Louise M. Jawerth, Stefan Münster, David A. Weitz, Fred C. MacKintosh
Soft Matter 6, 4120 (2010)
Divalent Cations Crosslink Vimentin Intermediate Filament Tail Domains to Regulate Network Mechanics
Yi-Chia Lin, Chase P. Broedersz, Amy C. Rowat, Tatjana Wedig, Harald Herrmann, Fred C. MacKintosh, David A. Weitz
Journal of Molecular Biology 399, 637-644 (2010)
Elasticity in ionically cross-linked neurofilament networks
Norman Y. Yao, Chase P. Broedersz, Yi-Chia Lin, Karen E. Kasza, Fred C. MacKintosh, David A. Weitz
Biophysical Journal 98, 2147-2153 (2010)
Origins of elasticity in intermediate filament networks
Yi-Chia Lin, Norman Y. Yao, Chase P. Broedersz, Harald Herrmann, Fred C. MacKintosh, David A. Weitz
Phys. Rev. Lett. 104, 058101 (2010)
Actin filament length tunes elasticity of flexibly crosslinked actin networks
Karen E. Kasza, Chase P. Broedersz, Gijsje H. Koenderink, Yin-Chia. Lin, W. Messner, E. A. Millman, F. Nakamura, T. P. Stossel, Fred C. MacKintosh, David A. Weitz
Biophysical Journal 99, 1091 (2010)
2009
Hydrogenography of MgyNi1-yHx gradient thin films: Interplay between the thermodynamics and kinetics of hydrogenation
Robin Gremaud, Chase P. Broedersz, Andreas Borgschulte, Michiel J. van Setten, Herman Schreuders, Martin Slaman, Bernard Dam, Ronald Griessen
Acta Mater. 58, 658-668 (2009)
Effective medium approach for stiff polymer networks with flexible cross-links
Chase P. Broedersz, Cornelis Storm, Fred C. MacKintosh
Phys. Rev. E 79, 061914 (2009) [arXiv:0811.3946]
Nonlinear elasticity of stiff biopolymers connected by flexible linkers
Karen E. Kasza, Gijsje H. Koenderink, Yi-Chia Lin, Chase P. Broedersz, W. Messner, F. Nakamura, T. P. Stossel, Fred C. MacKintosh, David A. Weitz
Phys. Rev. E 79, 041928 (2009)
2008
Nonlinear elasticity of composite networks of stiff biopolymers with flexible linkers
Chase P. Broedersz, Cornelis Storm, Fred C. MacKintosh
Phys. Rev. Lett. 101, 118103 (2008) [arXiv:0710.3951]
The highly destabilized Mg-Ti-Ni-H system investigated by density functional calculations and hydrogenography experiments
Chase P. Broedersz, Robin Gremaud, Bernard Dam, Ronald Griessen, Ole M. Lovvik
Phys. Rev. B 77, 024204 (2008)
Study of the hydride forming process of in-situ grown MgH2 thin films by activated reactive evaporation
Ruud J. Westerwaal, Chase P. Broedersz, Robin Gremaud, Martin Slaman, Andreas Borgschulte, Wiebke Lohstroh, Karl G. Tschersich, Hans P. Fleischhauer, Bernard Dam, Ronald Griessen
Thin Solid Films 516, 4351-4359 (2008)
2007
Hydrogenography: An Optical Combinatorial Method To Find New Light‐Weight Hydrogen‐Storage Materials
Robin Gremaud, Chase P. Broedersz, Dana M. Borsa, Andreas Borgschulte, Philippe Mauron, Herman Schreuders, Jan H. Rector, Bernard Dam, Ronald Griessen
Advanced Materials 19, 2813 – 2817 (2007)
Combinatorial thin film methods for the search of new light-weight metal-hydrides
Bernard Dam, Robin Gremaud, Chase P. Broedersz, Ronald Griessen
Scripta Materialia 56, 853-858 (2007)
2006
Optical, structural, and electrical properties of Mg2NiH4 thin films in-situ grown by activated reactive evaporation
Ruud J. Westerwaal, Martin Slaman, Andreas Borgschulte, Chase P. Broedersz, Dana M. Borsa, Wiebke Lohstroh, Bart J. Kooi, Gert ten Brink, Karl G. Tschersich, Hans P. Fleischhauer, Bernard Dam, Ronald Griessen
Journal of Applied Physics 100, 063518 (2006)