Project
The extracellular matrix (ECM) is a three-dimensional fibrous network of macromolecules that provides a scaffold for cells and maintains the integrity of tissues. The cues generated from probing ECM fibres, known as mechanosensing, help cells adjust their behavior. However, the ECM has an intricate mechanical response and can undergo irreversible transformations, which can lead to network remodelling. This project aims to establish a theoretical framework to obtain fundamental understanding on how cells behave individually and collectively by mechanically interacting with their surrounding environment. We will use biophysical experiments to develop and calibrate a computational model to simulate and quantitatively assess cell behavior and further advance knowledge on cell and tissue function. This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No 891217.
Curriculum Vitae
- 06/2020-present: Postdoc in the group of Chase Broedersz. Marie Curie Individual Fellowship – project CellMechSensE program H2020-EU.1.3.2., GA 891217.
- 09/2017-12/2019: Postdoc in the group of Karen Daniels, Physics Department, NCSU (USA). Study of the Mechanical Failure of Disordered Networks.
- 10/2012-12/2015: Ph.D. student in the group of Laurent Ponson, Institut Jean le Rond d’Alembert, UPMC (France). Study of the “Quasi-brittle failure of heterogeneous materials: damage statistics and localization”.
- 2009–2012: M.Sc.Eng. Materials sciences, Institut National des Sciences Appliquées (INSA) Lyon (France). Erasmus Program in 2010-2011 at Denmark Technical University (DTU), Denmark.
- 2011–2012: M.Sc. Materials sciences, Research Master in Innovative Materials, INSA Lyon (France)
- 2007-2009: B.Sc.Eng., INSA Rouen (France)
Publications
Local Nonlinear Elastic Response of Extracellular Matrices
Haiqian Yang , Estelle Berthier, Chenghai Li, Pierre Ronceray, Yu Long Han, Chase P. Broedersz, Shengqiang Cai, Ming Guo
submitted for publication [arXiv:2208.06386]
Nonlinear mechanosensation in fiber networks
Estelle Berthier, Haiqian Yang, Ming Guo, Pierre Ronceray, Chase P. Broedersz
submitted for publication [arXiv:2208.06328v1]
Forecasting failure locations in 2-dimensional disordered lattices
Estelle Berthier, Mason A. Porter, Karen E. Daniels
PNAS 116, 16742-16749 (2019) [News Summary]
Rigidity percolation control of the brittle-ductile transition in disordered networks
Estelle Berthier, Jonathan E. Kollmer, Silke E. Henkes, Kuang Liu, J. M. Schwarz, Karen E. Daniels
Physical Review Materials 3, 075602 (2019)
Collective Damage Growth Controls Fault Orientation in Quasibrittle Compressive Failure
Véronique Dansereau, Vincent Démery, Estelle Berthier, Jérôme Weiss, Laurent Ponson
Physical Review Letters 122, 085501 (2019)
Damage spreading in quasi-brittle disordered solids: I. Localization and failure
Estelle Berthier Vincent Démery Laurent Ponson
Journal of the Mechanics and Physics of Solids 102, 101-124 (2017)