Project and Research Interests
- Dynamics of cell migration in complex and confining environments
- Cell-cell interactions and collective migration
- Inference from stochastic trajectories
- Active contraction of biopolymer networks
- Interactions of cells with their elastic microenvironment
Curriculum Vitae
- 2021: NOMIS Foundation Postdoctoral Fellowship
- 2020: “Scientific Breakthrough” Award by the Center of NanoScience Munich
- 2020: “Young Researcher Prize” from the Solvay Institute “Physics of Living Systems” Workshop
- 2019: “Best Interdisciplinary Publication” Award by the Center of NanoScience Munich
- 2018-2021: Add-on Fellowship by the Joachim Herz Foundation
- 09/2016 to date: PhD student in the group of Prof. Dr. Chase Broedersz. Supported by the graduate school of Quantitative Biosciences Munich (QBM).
- 2016: Master Thesis on the “Hydrodynamics of Colloids in an External Field”, a simulation study using Multi-Particle Collision dynamics to elucidate the mechanism of colloidal particle migration in temperature fields. Supervised by Dr. Erika Eiser and Prof. Dr. Daan Frenkel, University of Cambridge.
- 2015 – 2016: Masters Degree in Physics, University of Cambridge, UK.
- 2012 – 2016: Scholarship by the Studienstiftung des deutschen Volkes.
- 2012 – 2015: Bachelors Degree in Physics, University of Cambridge, UK.
Publications
Geometry adaptation of protrusion and polarity dynamics in confined cell migration
David B. Brückner, Matthew Schmitt, Alexandra Fink, Georg Ladurner, Johannes Flommersfeld, Nicolas Arlt, Edouard Hannezo, Joachim O. Rädler, Chase P. Broedersz
Phys. Rev. X 12, 031041, Physics Magazine, [arXiv:2106.01014]
3D printed protein-based robotic structures actuated by molecular motor-based cortices
Haiyang Jia, Johannes Flommersfeld, Michael Heymann, Sven Vogel, Henri Franquelim, David B. Brückner, Hiromune Eto, Chase P. Broedersz+, Petra Schwille+
Nature Materials 21, 703–709 (2022) [preprint]
Disentangling cadherin-mediated cell-cell interactions in collective cancer cell migration
Themistoklis Zisis, David B. Brückner, Tom Brandstätter, Joseph d’Alessandro, Angelika M. Vollmar, Chase P. Broedersz, Stefan Zahler
submitted for publication [bioRxiv:2021.05.07.442718]
Learning the dynamics of cell-cell interactions in confined cell migration
David B. Brückner, Nicolas Arlt, Alexandra Fink, Pierre Ronceray, Joachim O. Rädler, Chase P. Broedersz
PNAS 118 (7), e2016602118 (2021) [arXiv:2008.03978] [LMU Press Release]
Inferring the Dynamics of Underdamped Stochastic Systems
David B. Brückner, Pierre Ronceray, Chase P. Broedersz
Physical Review Letters 125, 058103 (2020), featured as Editors’ suggestion [arXiv:2002.06680]
Disentangling the Behavioural Variability of Confined Cell Migration
David B. Brückner, Alexandra Fink, Joachim O. Rädler, Chase P. Broedersz
Journal of the Royal Society Interface 17, 20190689 (2020) [arXiv:1910.02815] [bioRxiv:10.1101/797555]
Area and geometry dependence of cell migration in asymmetric two-state micropatterns
Alexandra Fink, David B. Brückner, Christoph Schreiber, Peter Röttgermann, Chase P. Broedersz, Joachim O. Rädler
Biophysical Journal, 118, 552-564 (2019) [bioRxiv:10.1101/815472]
Morphology and Motility of Cells on Soft Substrates
Andriy Goychuk, David B. Brückner, Andrew W. Holle, Joachim P. Spatz, Chase P. Broedersz, Erwin Frey
submitted for publication [arXiv:1808.00314]
Stochastic nonlinear dynamics of confined cell migration in two-state systems
David B. Brückner, Alexandra Fink, Christoph Schreiber, Peter Röttgermann, Joachim O. Rädler, Chase P. Broedersz
Nature Physics 15, 595–601 (2019) [Nature Physics News & Views] [LMU Press Release]
Thermophoretic forces on a mesoscopic scale
Jérôme Burelbach, David B. Brückner, Daan Frenkel, Erika Eiser
Soft Matter 14, 7446-7454 (2018)
Guiding 3D cell migration in deformed synthetic hydrogel microstructures
Miriam Dietrich, Hugo Le Roy, David B. Brückner, Hanna Engelke, Roman Zantl, Joachim O. Rädler, Chase P. Broedersz
Soft Matter 14, 2816-2826 (2018)